Billionaire Profile
Leonard Schleifer
Global Rank
#1408

Image: Public domain | via Wikimedia Commons

Leonard Schleifer

CEO, Regeneron Pharmaceuticals
US
Real-Time Net Worth
$2.8B
As of December 2025
Age
73
Source
Pharmaceuticals
Industry
healthcare
Citizenship
US

Biography

Leonard Schleifer is the co-founder and CEO of Regeneron Pharmaceuticals, a leading biotechnology company focused on developing innovative medicines. With a net worth of $2.8 billion, Schleifer's wealth stems from his work in the Pharmaceuticals industry. His career includes founding Regeneron in 1988, where he has overseen the development of several FDA-approved treatments. He has been instrumental in Regeneron's achievements, including the breakthrough drug Eylea for macular degeneration. A licensed physician and neurologist, Schleifer holds degrees from Cornell University and the University of Virginia.

Wealth Over Time

In-Depth Profile

Early Life

Leonard S. Schleifer was born in 1953 in Queens, New York, to a Jewish family. His father was a sweater manufacturer and a World War II codebreaker. He graduated with a B.S. from Cornell University and earned an MD-PhD from the University of Virginia, studying under future Nobel Laureate Alfred G. Gilman.

Rise to Success

In 1988, Schleifer co-founded Regeneron Pharmaceuticals with George Yancopoulos. Initially, the company faced challenges. However, Schleifer's strategic pivot to focus on well-understood biology and human testing under the guidance of former Merck & Co. CEO Roy Vagelos led to the breakthrough drug Eylea, approved in 2011. Eylea prevents leaky blood vessels in the eye from causing blindness. He took Regeneron public in 1991.

Key Business Strategies

Schleifer's leadership style emphasizes a strong commitment to research and development, fostering a culture of scientific excellence at Regeneron. His strategic initiatives have propelled the company to the forefront of biotechnology and solidified its reputation for transformative therapies. Sales of Eylea reached $5.7 billion in the U.S. in 2023. Regeneron has developed 12 FDA-approved medicines.

Philanthropy

Schleifer has supported the Jewish Community Center (JCC) operations and inclusion programs, and he and his wife donated to the JCC Capital Campaign.

Career Milestones

1988

Co-founded Regeneron Pharmaceuticals

Co-founded Regeneron with George Yancopoulos.

1991

Regeneron goes public

Schleifer took Regeneron public.

2011

Eylea Approval

Eylea, a treatment for age-related macular degeneration, was approved.

2014

Became a Billionaire

Schleifer's net worth crossed the $1 billion threshold.

Philanthropy & Social Impact

Community Support

JCC Capital Campaign

$XB

Donation to the JCC Capital Campaign

Community Support

JCC Operations

$XB

Additional gifts to JCC operations

Community Support

Inclusion Programs

$XB

Donations to JCC inclusion programs

Business Philosophy & Leadership

Notable Quotes

""Most people, they lose their edge. We just push the edge further forward.""

Leadership Principles

Commitment to Science

Schleifer emphasized the importance of rigorous scientific research.

Persistence

He is known for his persistence and willingness to overcome challenges.

Focus on Unmet Medical Needs

Prioritizing drugs for disorders whose biology is fully understood.

Controversies & Challenges

2020

COVID-19 Therapeutic Access

Privileged access of experimental COVID-19 therapeutic to Donald Trump and his administration raised ethical concerns.